Secondary malignancies in chronic myeloid leukemia patients after imatinib-based treatment: long-term observation in CML Study IV
Identifieur interne : 000093 ( Main/Exploration ); précédent : 000092; suivant : 000094Secondary malignancies in chronic myeloid leukemia patients after imatinib-based treatment: long-term observation in CML Study IV
Auteurs : M B Miranda [Allemagne] ; M. Lauseker [Allemagne] ; M-P Kraus [Allemagne] ; U. Proetel [Allemagne] ; B. Hanfstein [Allemagne] ; A. Fabarius [Allemagne] ; G M Baerlocher [Suisse] ; D. Heim [Suisse] ; D K Hossfeld [Allemagne] ; H-J Kolb [Allemagne] ; S W Krause [Allemagne] ; C. Nerl [Allemagne] ; T H Brümmendorf [Allemagne] ; W. Verbeek [Allemagne] ; A A Fauser [Allemagne] ; O. Prümmer [Allemagne] ; K. Neben [Allemagne] ; U. Hess [Suisse] ; R. Mahlberg [Allemagne] ; C. Plöger [Allemagne] ; M. Flasshove [Allemagne] ; B. Rendenbach [Allemagne] ; W-K Hofmann [Allemagne] ; M C Müller [Allemagne] ; M. Pfirrmann [Allemagne] ; A. Hochhaus [Allemagne] ; J. Hasford [Allemagne] ; R. Hehlmann [Allemagne] ; S. Sau Ele [Allemagne]Source :
- Leukemia [ 0887-6924 ] ; 2016.
Abstract
Treatment of chronic myeloid leukemia (CML) has been profoundly improved by the introduction of tyrosine kinase inhibitors (TKIs). Long-term survival with imatinib is excellent with a 8-year survival rate of ∼88%. Long-term toxicity of TKI treatment, especially carcinogenicity, has become a concern. We analyzed data of the CML study IV for the development of secondary malignancies. In total, 67 secondary malignancies were found in 64 of 1525 CML patients in chronic phase treated with TKI (
Url:
DOI: 10.1038/leu.2016.20
PubMed: 26859076
PubMed Central: 4895174
Affiliations:
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Lauseker</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraus, M P" sort="Kraus, M P" uniqKey="Kraus M" first="M-P" last="Kraus">M-P Kraus</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Proetel, U" sort="Proetel, U" uniqKey="Proetel U" first="U" last="Proetel">U. 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Fabarius</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baerlocher, G M" sort="Baerlocher, G M" uniqKey="Baerlocher G" first="G M" last="Baerlocher">G M Baerlocher</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor, Inselspital</institution>, Bern,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heim, D" sort="Heim, D" uniqKey="Heim D" first="D" last="Heim">D. Heim</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Klinik für Hämatologie, Universitätsspital</institution>, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hossfeld, D K" sort="Hossfeld, D K" uniqKey="Hossfeld D" first="D K" last="Hossfeld">D K Hossfeld</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>II. Medizinische Klinik, Universitätsklinikum Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolb, H J" sort="Kolb, H J" uniqKey="Kolb H" first="H-J" last="Kolb">H-J Kolb</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Medizinische Klinik und Poliklinik III, Klinikum der Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krause, S W" sort="Krause, S W" uniqKey="Krause S" first="S W" last="Krause">S W Krause</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Medizinische Klinik 5, Universitätsklinikum</institution>, Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nerl, C" sort="Nerl, C" uniqKey="Nerl C" first="C" last="Nerl">C. Nerl</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Klinik für Hämatologie, Onkologie, Immunologie, Palliativmedizin, Infektiologie und Tropenmedizin, Klinikum Schwabing</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brummendorf, T H" sort="Brummendorf, T H" uniqKey="Brummendorf T" first="T H" last="Brümmendorf">T H Brümmendorf</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Medizinische Klinik IV, Uniklinik RWTH</institution>, Aachen<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verbeek, W" sort="Verbeek, W" uniqKey="Verbeek W" first="W" last="Verbeek">W. Verbeek</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Zentrum für ambulante Hämatologie und Onkologie</institution>, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fauser, A A" sort="Fauser, A A" uniqKey="Fauser A" first="A A" last="Fauser">A A Fauser</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Klinik für Knochenmarktransplantation und Hämatologie/Onkologie, Klinikum</institution>, Idar-Oberstein,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prummer, O" sort="Prummer, O" uniqKey="Prummer O" first="O" last="Prümmer">O. Prümmer</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Klinik für Hämatologie, Onkologie und Palliativmedizin, Klinikum</institution>, Kempten,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neben, K" sort="Neben, K" uniqKey="Neben K" first="K" last="Neben">K. Neben</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Medizinische Klinik 2, Klinikum Mittelbaden, Standort Balg</institution>, Baden-Baden,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hess, U" sort="Hess, U" uniqKey="Hess U" first="U" last="Hess">U. Hess</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Klinik für Onkologie/Hämatologie, Kantonsspital</institution>, St Gallen,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mahlberg, R" sort="Mahlberg, R" uniqKey="Mahlberg R" first="R" last="Mahlberg">R. Mahlberg</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Innere Medizin 1, Klinikum Mutterhaus der Borromäerinnen</institution>, Trier,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ploger, C" sort="Ploger, C" uniqKey="Ploger C" first="C" last="Plöger">C. Plöger</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Mannheimer Onkologie Praxis</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Flasshove, M" sort="Flasshove, M" uniqKey="Flasshove M" first="M" last="Flasshove">M. Flasshove</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Medizinische Klinik III, Krankenhaus</institution>, Düren,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rendenbach, B" sort="Rendenbach, B" uniqKey="Rendenbach B" first="B" last="Rendenbach">B. Rendenbach</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Praxis für Innere Medizin, Nephrologie, Hämatologie und Onkologie</institution>, Trier,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofmann, W K" sort="Hofmann, W K" uniqKey="Hofmann W" first="W-K" last="Hofmann">W-K Hofmann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfirrmann, M" sort="Pfirrmann, M" uniqKey="Pfirrmann M" first="M" last="Pfirrmann">M. Pfirrmann</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Klinik für Innere Medizin II, Universitätsklinikum</institution>, Jena,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hasford, J" sort="Hasford, J" uniqKey="Hasford J" first="J" last="Hasford">J. Hasford</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hehlmann, R" sort="Hehlmann, R" uniqKey="Hehlmann R" first="R" last="Hehlmann">R. Hehlmann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sau Ele, S" sort="Sau Ele, S" uniqKey="Sau Ele S" first="S" last="Sau Ele">S. Sau Ele</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26859076</idno><idno type="pmc">4895174</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895174</idno><idno type="RBID">PMC:4895174</idno><idno type="doi">10.1038/leu.2016.20</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000037</idno><idno type="wicri:Area/Pmc/Curation">000037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000037</idno><idno type="wicri:Area/Pmc/Checkpoint">000007</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000007</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000132</idno><idno type="wicri:Area/PubMed/Curation">000132</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000132</idno><idno type="wicri:Area/PubMed/Checkpoint">000132</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000132</idno><idno type="wicri:Area/Ncbi/Merge">000893</idno><idno type="wicri:Area/Ncbi/Curation">000893</idno><idno type="wicri:Area/Ncbi/Checkpoint">000893</idno><idno type="wicri:doubleKey">0887-6924:2016:Miranda M:secondary:malignancies:in</idno><idno type="wicri:Area/Main/Merge">000093</idno><idno type="wicri:Area/Main/Curation">000093</idno><idno type="wicri:Area/Main/Exploration">000093</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Secondary malignancies in chronic myeloid leukemia patients after imatinib-based treatment: long-term observation in CML Study IV</title><author><name sortKey="Miranda, M B" sort="Miranda, M B" uniqKey="Miranda M" first="M B" last="Miranda">M B Miranda</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lauseker, M" sort="Lauseker, M" uniqKey="Lauseker M" first="M" last="Lauseker">M. Lauseker</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kraus, M P" sort="Kraus, M P" uniqKey="Kraus M" first="M-P" last="Kraus">M-P Kraus</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Proetel, U" sort="Proetel, U" uniqKey="Proetel U" first="U" last="Proetel">U. Proetel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hanfstein, B" sort="Hanfstein, B" uniqKey="Hanfstein B" first="B" last="Hanfstein">B. Hanfstein</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fabarius, A" sort="Fabarius, A" uniqKey="Fabarius A" first="A" last="Fabarius">A. Fabarius</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baerlocher, G M" sort="Baerlocher, G M" uniqKey="Baerlocher G" first="G M" last="Baerlocher">G M Baerlocher</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor, Inselspital</institution>, Bern,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heim, D" sort="Heim, D" uniqKey="Heim D" first="D" last="Heim">D. Heim</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Klinik für Hämatologie, Universitätsspital</institution>, Basel,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hossfeld, D K" sort="Hossfeld, D K" uniqKey="Hossfeld D" first="D K" last="Hossfeld">D K Hossfeld</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>II. Medizinische Klinik, Universitätsklinikum Eppendorf</institution>, Hamburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kolb, H J" sort="Kolb, H J" uniqKey="Kolb H" first="H-J" last="Kolb">H-J Kolb</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Medizinische Klinik und Poliklinik III, Klinikum der Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krause, S W" sort="Krause, S W" uniqKey="Krause S" first="S W" last="Krause">S W Krause</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Medizinische Klinik 5, Universitätsklinikum</institution>, Erlangen,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nerl, C" sort="Nerl, C" uniqKey="Nerl C" first="C" last="Nerl">C. Nerl</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Klinik für Hämatologie, Onkologie, Immunologie, Palliativmedizin, Infektiologie und Tropenmedizin, Klinikum Schwabing</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brummendorf, T H" sort="Brummendorf, T H" uniqKey="Brummendorf T" first="T H" last="Brümmendorf">T H Brümmendorf</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Medizinische Klinik IV, Uniklinik RWTH</institution>, Aachen<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Verbeek, W" sort="Verbeek, W" uniqKey="Verbeek W" first="W" last="Verbeek">W. Verbeek</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Zentrum für ambulante Hämatologie und Onkologie</institution>, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fauser, A A" sort="Fauser, A A" uniqKey="Fauser A" first="A A" last="Fauser">A A Fauser</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Klinik für Knochenmarktransplantation und Hämatologie/Onkologie, Klinikum</institution>, Idar-Oberstein,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Prummer, O" sort="Prummer, O" uniqKey="Prummer O" first="O" last="Prümmer">O. Prümmer</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Klinik für Hämatologie, Onkologie und Palliativmedizin, Klinikum</institution>, Kempten,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neben, K" sort="Neben, K" uniqKey="Neben K" first="K" last="Neben">K. Neben</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Medizinische Klinik 2, Klinikum Mittelbaden, Standort Balg</institution>, Baden-Baden,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hess, U" sort="Hess, U" uniqKey="Hess U" first="U" last="Hess">U. Hess</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Klinik für Onkologie/Hämatologie, Kantonsspital</institution>, St Gallen,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mahlberg, R" sort="Mahlberg, R" uniqKey="Mahlberg R" first="R" last="Mahlberg">R. Mahlberg</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Innere Medizin 1, Klinikum Mutterhaus der Borromäerinnen</institution>, Trier,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ploger, C" sort="Ploger, C" uniqKey="Ploger C" first="C" last="Plöger">C. Plöger</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Mannheimer Onkologie Praxis</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Flasshove, M" sort="Flasshove, M" uniqKey="Flasshove M" first="M" last="Flasshove">M. Flasshove</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Medizinische Klinik III, Krankenhaus</institution>, Düren,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rendenbach, B" sort="Rendenbach, B" uniqKey="Rendenbach B" first="B" last="Rendenbach">B. Rendenbach</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Praxis für Innere Medizin, Nephrologie, Hämatologie und Onkologie</institution>, Trier,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hofmann, W K" sort="Hofmann, W K" uniqKey="Hofmann W" first="W-K" last="Hofmann">W-K Hofmann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfirrmann, M" sort="Pfirrmann, M" uniqKey="Pfirrmann M" first="M" last="Pfirrmann">M. Pfirrmann</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Klinik für Innere Medizin II, Universitätsklinikum</institution>, Jena,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hasford, J" sort="Hasford, J" uniqKey="Hasford J" first="J" last="Hasford">J. Hasford</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität</institution>, München,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hehlmann, R" sort="Hehlmann, R" uniqKey="Hehlmann R" first="R" last="Hehlmann">R. Hehlmann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sau Ele, S" sort="Sau Ele, S" uniqKey="Sau Ele S" first="S" last="Sau Ele">S. Sau Ele</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>III. Medizinische Klinik, Universitätsmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg</institution>, Mannheim,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="ISSN">0887-6924</idno><idno type="eISSN">1476-5551</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Treatment of chronic myeloid leukemia (CML) has been profoundly improved by the introduction of tyrosine kinase inhibitors (TKIs). Long-term survival with imatinib is excellent with a 8-year survival rate of ∼88%. Long-term toxicity of TKI treatment, especially carcinogenicity, has become a concern. We analyzed data of the CML study IV for the development of secondary malignancies. In total, 67 secondary malignancies were found in 64 of 1525 CML patients in chronic phase treated with TKI (<italic>n=</italic>61) and interferon-α only (<italic>n=</italic>3). The most common malignancies (<italic>n</italic>⩾4) were prostate, colorectal and lung cancer, non-Hodgkin's lymphoma (NHL), malignant melanoma, non-melanoma skin tumors and breast cancer. The standardized incidence ratio (SIR) for all malignancies excluding non-melanoma skin tumors was 0.88 (95% confidence interval (0.63–1.20)) for men and 1.06 (95% CI 0.69–1.55) for women. SIRs were between 0.49 (95% CI 0.13–1.34) for colorectal cancer in men and 4.29 (95% CI 1.09–11.66) for NHL in women. The SIR for NHL was significantly increased for men and women. An increase in the incidence of secondary malignancies could not be ascertained. The increased SIR for NHL has to be considered and long-term follow-up of CML patients is warranted, as the rate of secondary malignancies may increase over time.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Miranda, M B" sort="Miranda, M B" uniqKey="Miranda M" first="M B" last="Miranda">M B Miranda</name></noRegion><name sortKey="Brummendorf, T H" sort="Brummendorf, T H" uniqKey="Brummendorf T" first="T H" last="Brümmendorf">T H Brümmendorf</name><name sortKey="Fabarius, A" sort="Fabarius, A" uniqKey="Fabarius A" first="A" last="Fabarius">A. Fabarius</name><name sortKey="Fauser, A A" sort="Fauser, A A" uniqKey="Fauser A" first="A A" last="Fauser">A A Fauser</name><name sortKey="Flasshove, M" sort="Flasshove, M" uniqKey="Flasshove M" first="M" last="Flasshove">M. Flasshove</name><name sortKey="Hanfstein, B" sort="Hanfstein, B" uniqKey="Hanfstein B" first="B" last="Hanfstein">B. Hanfstein</name><name sortKey="Hasford, J" sort="Hasford, J" uniqKey="Hasford J" first="J" last="Hasford">J. Hasford</name><name sortKey="Hehlmann, R" sort="Hehlmann, R" uniqKey="Hehlmann R" first="R" last="Hehlmann">R. Hehlmann</name><name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name><name sortKey="Hofmann, W K" sort="Hofmann, W K" uniqKey="Hofmann W" first="W-K" last="Hofmann">W-K Hofmann</name><name sortKey="Hossfeld, D K" sort="Hossfeld, D K" uniqKey="Hossfeld D" first="D K" last="Hossfeld">D K Hossfeld</name><name sortKey="Kolb, H J" sort="Kolb, H J" uniqKey="Kolb H" first="H-J" last="Kolb">H-J Kolb</name><name sortKey="Kraus, M P" sort="Kraus, M P" uniqKey="Kraus M" first="M-P" last="Kraus">M-P Kraus</name><name sortKey="Krause, S W" sort="Krause, S W" uniqKey="Krause S" first="S W" last="Krause">S W Krause</name><name sortKey="Lauseker, M" sort="Lauseker, M" uniqKey="Lauseker M" first="M" last="Lauseker">M. Lauseker</name><name sortKey="Mahlberg, R" sort="Mahlberg, R" uniqKey="Mahlberg R" first="R" last="Mahlberg">R. Mahlberg</name><name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name><name sortKey="Neben, K" sort="Neben, K" uniqKey="Neben K" first="K" last="Neben">K. Neben</name><name sortKey="Nerl, C" sort="Nerl, C" uniqKey="Nerl C" first="C" last="Nerl">C. Nerl</name><name sortKey="Pfirrmann, M" sort="Pfirrmann, M" uniqKey="Pfirrmann M" first="M" last="Pfirrmann">M. Pfirrmann</name><name sortKey="Ploger, C" sort="Ploger, C" uniqKey="Ploger C" first="C" last="Plöger">C. Plöger</name><name sortKey="Proetel, U" sort="Proetel, U" uniqKey="Proetel U" first="U" last="Proetel">U. Proetel</name><name sortKey="Prummer, O" sort="Prummer, O" uniqKey="Prummer O" first="O" last="Prümmer">O. Prümmer</name><name sortKey="Rendenbach, B" sort="Rendenbach, B" uniqKey="Rendenbach B" first="B" last="Rendenbach">B. Rendenbach</name><name sortKey="Sau Ele, S" sort="Sau Ele, S" uniqKey="Sau Ele S" first="S" last="Sau Ele">S. Sau Ele</name><name sortKey="Verbeek, W" sort="Verbeek, W" uniqKey="Verbeek W" first="W" last="Verbeek">W. Verbeek</name></country><country name="Suisse"><noRegion><name sortKey="Baerlocher, G M" sort="Baerlocher, G M" uniqKey="Baerlocher G" first="G M" last="Baerlocher">G M Baerlocher</name></noRegion><name sortKey="Heim, D" sort="Heim, D" uniqKey="Heim D" first="D" last="Heim">D. Heim</name><name sortKey="Hess, U" sort="Hess, U" uniqKey="Hess U" first="U" last="Hess">U. Hess</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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